Mechanism for Development of Nanobased Drug Delivery System (2025)

Mucoadhesive Nanocarriers as a Promising Strategy to Enhance Intracellular Delivery against Oral Cavity Carcinoma

Manisha Pandey, Hira Choudhury, Jenifer Ngu Shao Ying, Jessica Foo Sze Ling, Jong Ting, Jocelyn Su Szhiou Ting, Ivory Kuek Zhia Hwen, Ho Wan Suen, Hazimah Syazwani Samsul Kamar, Bapi Gorain, Neha Jain, Mohd Cairul Iqbal Mohd Amin

Oral cancer, particularly squamous cell carcinoma (SCC), has posed a grave challenge to global health due to its high incidence, metastasis, and mortality rates. Despite numerous studies and favorable improvements in the therapeutic strategies over the past few decades, the prognosis of this disease remains dismal. Moreover, several drawbacks are associated with the conventional treatment; including permanent disfigurement and physical impairment that are attributed to surgical intervention, and systemic toxicity that results from aggressive radio- or chemotherapies, which impacts patients’ prognosis and post-treatment quality of life. The highly vascularized, non-keratinized oral mucosa appears as a potential route for cytotoxic drug administration in treating oral cancer. It acts as a non-invasive portal for drug entry targeting the local oral lesions of the early stages of cancer and the systemic metastasis sites of advanced cancer. The absorption of the poorly aqueous-soluble anti-cancer drugs can be enhanced due to the increased permeability of the ulcerous mucosa lining in the disease state and by bypassing the hepatic first-pass metabolism. However, some challenges in oral transmucosal drug delivery include the drugs’ taste, the limited surface area of the membrane lining the oral cavity, and flushing and enzymatic degradation by saliva. Therefore, mucoadhesive nanocarriers have emerged as promising platforms for controlled, targeted drug delivery in the oral cavity. The surface functionalization of nanocarriers with various moieties allows for drug targeting, bioavailability enhancement, and biodistribution at the site of action, while the mucoadhesive feature prolongs the drug’s residence time for preferential accumulation to optimize the therapeutic effect and reduce systemic toxicity. This review has been focused to highlight the potential of various nanocarriers (e.g., nanoparticles, nanoemulsions, nanocapsules, and liposomes) in conferring targeting, solubility and bioavailability enhancement of actives and mucoadhesive properties as novel tumor-targeted drug delivery approaches in oral cancer treatment.

2022, Pharmaceutics, №4, с.795

Block Co-polymers: Vital Aspects and Applications in Drug Delivery

Parag Bhayana, Priya Bhat, Rupshee Jain, Neha Raina, Atul Jain, Teenu Sharma

2023, Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications, с.355-380

Cubosomes as an emerging platform for drug delivery: a review of the state of the art

Mohammed A.S. Abourehab, Mohammad Javed Ansari, Anshul Singh, Ahmed Hassan, Mohamed A. Abdelgawad, Prachi Shrivastav, Bassam M. Abualsoud, Larissa Souza Amaral, Sheersha Pramanik

Cubosomes, derived from LLCs, are self-assembled cubic-phase bicontinuous crystalline nanoparticulate colloidal dispersions. This review sheds light on different aspects of cubosomes, particularly on the prospective drug delivery routes.

2022, Journal of Materials Chemistry B, №15, с.2781-2819

Bacterial Cellulose for Drug Delivery: Current Status and Opportunities

Shivakalyani Adepu, Sailaja Bodrothu, Mudrika Khandelwal

2022, Indian Institute of Metals Series New Horizons in Metallurgy, Materials and Manufacturing, с.137-157

Polymeric and Inorganic Nanoparticles Targeting Chronic Respiratory Diseases

Yinghan Chan, Sin Wi Ng, Laura Soon

2022, Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, с.375-433

Gemini Surfactant as a Template Agent for the Synthesis of More Eco-Friendly Silica Nanocapsules

Olga Kaczerewska, Isabel Sousa, Roberto Martins, Joana Figueiredo, Susana Loureiro, João Tedim

Silica mesoporous nanocapsules are a class of “smart” engineered nanomaterials (ENMs) applied in several fields. Recent studies have highlighted that they can exert deleterious effects into marine organisms, attributed to the use of the toxic cationic surfactant N-hexadecyl-N,N,N-trimethylammonium bromide (CTAB) during the synthesis of ENMs. The present study reports the successful synthesis and characterization of novel gemini surfactant-based silica nanocapsules. The gemini surfactant 1,4-bis-[N-(1-dodecyl)-N,N-dimethylammoniummethyl]benzene dibromide (QSB2-12) was chosen as a more environmentally-friendly replacement of CTAB. Nanocapsules were characterized by scanning electron microscopy (SEM), Fourier-transformed infrared spectroscopy (FTIR), dynamic light scattering (DLS), thermogravimetric analysis (TGA) and N2 adsorption-desorption isotherms. Short-term exposure effects of new ENMs were evaluated in four marine species (Nannochloropsis gaditana, Tetraselmis chuii and Phaeodactylum tricornutum) and the microcrustacean (Artemia salina). The replacement of the commercial cationic surfactant by the gemini surfactant does not change the structure nor the environmental behaviour in seawater of the newly synthesised silica nanocontainers. Additionally, it is demonstrated that using gemini surfactants can reduce the toxicity of novel silica nanocapsules towards the tested marine species. As a result, environmentally-friendly ENMs can be obtained based on a safe-by-design approach, thereby fitting the concept of Green Chemistry.

2020, Applied Sciences, №22, с.8085

Emerging Era in Colloidal Carriers Approach for Enhanced Transdermal Drug Delivery

Mridul Modgil, Abhishek Sharma

<jats:sec> <jats:title/> Colloidal carriers are a promising type of carriers which play a crucial role in transdermal drug delivery and other topical applications. These carriers are usually present in the microscopic size, which offers different methods to enclose and deliver a diverse range of dynamic substances such as medicines, genes, and lipids. They offer distinct advantages by mimicking the natural structure of the skin's lipid bilayers using lipids and allowing the incorporation of different active compounds through the use of polymers. Recently, more advanced technology like artificial intelligence (AI) and machine learning (ML) has been adopted in the pharmaceutical field. The incorporation of artificial intelligence and machine learning techniques in colloidal carriers holds immense promise in revolutionizing the domain of drug delivery and nanomedicine. Machine learning algorithms can undergo training with the use of extensive datasets containing information on drug behavior within the human body, which can predict drug response within the body. Additionally, AI can be employed to anticipate various processes, thereby resulting in an enhanced delivery of medication using carriers. Many studies have shown the use of machine learning (ML) and artificial intelligence (AI) for optimizing the drug-carrying capacity via colloidal carriers. The present review concentrates on various categories of innovative colloidal vehicles in transdermal administration, alongside their penetration technique, benefit, and mechanism in the integumentary system. Outcomes from the different researches are critically assessed and showcase the potential of colloidal carriers to augment the penetration of drugs through the stratum corneum while minimizing adverse effects on the entire system with improved therapeutic effectiveness in various diseases. </jats:sec>

2024, Current Nanoscience, №2, с.218-241

Polymer - Metal Nanocomplexes Based Delivery System: A Boon for Agriculture Revolution

Pawan Kaur, Rita Choudhary, Anamika Pal, Chanchal Mony, Alok Adholeya

<jats:sec><jats:title />Metal nanoparticles are well known for their antimicrobial properties. The use of metalbased nanoparticles in the agricultural field has considerably increased globally by both direct and indirect means for the management of plant diseases. In this context, the development of controlled delivery systems for slow and sustained release of metal nanoparticles is crucial for prolonged antimicrobial activity. Polymers have emerged as a valuable carrier for controlled delivery of metal nanoparticles as agrochemicals because of their distinctive properties. The most significant benefits of encapsulating metal nanoparticles in a polymer matrix include the ability to function as a protector of metal nanoparticles and their controlled release with prolonged efficacy. This review focuses on loading strategies and releasing behavior of metal nanoparticles in the polymer matrix as antimicrobial agents for plant diseases. The Polymer-metal nanocomplexes (PMNs) comprise a biocompatible polymeric matrix and metal nanoparticles as active components of an antimicrobial agent, pesticides and plant growth regulators used to enhance the crop productivity.</jats:sec>

2020, Current Topics in Medicinal Chemistry, №11, с.1009-1028

Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases

Rahul Dev Bairagi, Raiyan Rahman Reon, Md Mahbub Hasan, Sumit Sarker, Dipa Debnath, Md. Tawhidur Rahman, Sinthia Rahman, Md. Amirul Islam, Md. Abu Talha Siddique, Bishwajit Bokshi, Md. Mustafizur Rahman, Amit Kumar Acharzo

2025, Discover Nano, №1

RNA Interference Nanotherapeutics for Treatment of Glioblastoma Multiforme

Prabhjeet Singh, Aditi Singh, Shruti Shah, Jalpa Vataliya, Anupama Mittal, Deepak Chitkara

2020, Molecular Pharmaceutics, №11, с.4040-4066